Homemade Southern Chicken Spaghetti Casserole

Name: Homemade Southern Chicken Spaghetti Casserole
Prep time: 15 min
Cook time: 30 min
Total time: 45 min
Yield: 8 servings
Ingredients: 3 cups cooked spaghetti; 2 cups shredded cooked chicken; 1 cup bell peppers, chopped; 1 cup cheddar cheese, shredded; 1 can cream of mushroom soup; 1 cup chicken broth; 1 teaspoon garlic powder; 1 teaspoon onion powder; Salt and pepper to taste

Highlighted under: Family Comfort Meals

Savor the comforting flavors of the South with this delicious Homemade Southern Chicken Spaghetti Casserole. Creamy, cheesy, and loaded with tender chicken, vibrant bell peppers, and savory spices, this dish is the perfect combination of hearty and satisfying. It's an easy, crowd-pleasing recipe that comes together quickly and is perfect for feeding a hungry family or entertaining guests.

Created by

Emma

Last updated on 2025-10-23T08:55:47.107Z

This Homemade Southern Chicken Spaghetti Casserole is a classic dish that brings warmth and comfort to any dinner table. Perfect for sharing with family and friends!

A Southern Comfort Classic

Southern cuisine is beloved for its rich, mouthwatering flavor, and this Homemade Southern Chicken Spaghetti Casserole embodies that spirit perfectly. Whether it’s a Sunday family dinner or a potluck gathering, this dish is sure to be a hit. The combination of savory chicken, creamy sauce, and tender spaghetti creates a warm, satisfying meal that's both nostalgic and familiar.

Chicken spaghetti has deep roots in Southern kitchens, often passed down through generations. As you flip through old family recipe books, you may discover variations influenced by local ingredients and personal touches. This casserole keeps the classic elements while adding a modern flair, making it a great dish to share or serve to guests who appreciate timeless culinary favorites.

Customization and Variations

One of the best aspects of this casserole is its versatility. You can easily tailor the recipe to suit your tastes or dietary needs. For instance, feel free to substitute cooked turkey or rotisserie chicken for a quicker cooking process. You can also mix in seasonal vegetables, like spinach or zucchini, which will not only add nutrition but also a burst of color to your dish.

If you're looking for a little extra heat, consider tossing in some diced jalapeños or a splash of hot sauce. On the other hand, for a creamier, richer flavor, you can swap out the cream of mushroom soup for cheese soup or a homemade béchamel sauce, making this dish your own while still honoring its Southern roots.

Ingredients

Main Ingredients

3 cups cooked spaghetti
2 cups shredded cooked chicken
1 cup bell peppers, chopped
1 cup cheddar cheese, shredded
1 can cream of mushroom soup
1 cup chicken broth
1 teaspoon garlic powder
1 teaspoon onion powder
Salt and pepper to taste

Make sure everything is prepped before you start assembling your casserole!

Instructions

Preheat the Oven

Preheat your oven to 350°F (175°C).

Mix Ingredients

In a large bowl, combine cooked spaghetti, chicken, bell peppers, cheddar cheese, cream of mushroom soup, chicken broth, garlic powder, and onion powder. Season with salt and pepper.

Transfer to Baking Dish

Pour the mixture into a greased 9x13 inch baking dish and spread evenly.

Bake

Bake in the preheated oven for 25-30 minutes, or until the cheese is bubbly and the edges are golden.

Serve

Let it cool for a few minutes before serving. Enjoy!

This casserole is best served warm and can be paired with a fresh salad.

Serving Suggestions

Serving this Homemade Southern Chicken Spaghetti Casserole is as delightful as making it. Pair it with a simple green salad for a balanced meal, bringing freshness and texture to the table. Garlic bread or biscuits make excellent sides, perfect for soaking up that creamy sauce. Don't forget to offer ice-cold sweet tea or lemonade, adding that quintessential Southern touch.

For gatherings, consider placing a variety of toppings at the table—sliced green onions, crumbled bacon, or additional cheese allow guests to personalize their servings. This interactive aspect not only enhances the dining experience but also sparks conversation among friends and family, making every meal memorable.

Storing and Reheating

If you have leftovers (though we doubt there will be any!), this casserole stores wonderfully. Let it cool completely, then transfer it to an airtight container and refrigerate for up to three days. For longer storage, consider freezing portions. Wrap individual servings tightly with plastic wrap and foil, and they can last up to three months in the freezer.

When you're ready to enjoy it again, reheating is a breeze. For the best results, thaw any frozen servings overnight in the refrigerator. Reheat in the oven at 350°F (175°C) for about 20-25 minutes, or until heated through. You can also use the microwave, but be sure to check frequently to avoid overcooking. Freshening it up with a sprinkle of cheese before reheating can help maintain that creamy, cheesy goodness!

Questions About Recipes

→ Can I use frozen chicken?

Yes, just ensure it's fully cooked before adding it to the casserole.

→ Can this be made ahead of time?

Absolutely! You can prepare it a day in advance and store it in the refrigerator before baking.